A day after several vaccine makers signed a safety pledge, one of the companies racing to make a vaccine against COVID-19 seems to have hit a stumbling block.
AstraZeneca put a hold on its COVID-19 clinical trials worldwide while it investigated an adverse reaction in a trial participant in the United Kingdom. The interruption represents the first major hiccup in what has been a remarkably smooth path in the historically rapid vaccine effort spanning the globe. That said, large scale, make-or-break Phase 3 clinical trials are where real issues are most likely to occur.
The news comes as the United States on track to record its 190,000th death from COVID-19 on Wednesday.
Meanwhile, at a campaign rally in Winston-Salem, North Carolina, on Tuesday, President Donald Trump accused the state's governor of using coronavirus restrictions to hurt his reelection chances. It's Trump's third appearance in as many weeks in North Carolina, a crucial state he needs to win in order to secure his reelection. He won the Tar Heel State by nearly 4% but national polls show him deadlocked with Democratic presidential candidate Joe Biden, according to a RealClearPolitics average of polls.
Some significant developments:
- Five counties in California, including Orange County south of Los Angeles, are moving ahead with reopening plans amid a decline in confirmed coronavirus cases across the state. Places of worship, restaurants with indoor dining and movie theaters will soon be allowed to reopen at 25% capacity, Gov. Gavin Newsom announced Tuesday.
- Honolulu is extending stay-at-home orders for another two weeks amid a surge in cases.
- Internationally, India reported another 89,000 cases on Wednesday after becoming the world's second hardest-hit country the previous day.
- The Transportation Security Agency reported its busiest day since March over the Labor Day weekend: Some 935,000 passengers went through TSA checkpoints on Saturday.
- Senate Republicans unveiled a coronavirus relief plan far smaller than what lawmakers on both sides of the aisle spent weeks arguing over. It's a bill that even Senate Majority Leader Mitch McConnell says isn't perfect. Here's what it includes.
📈 Today's numbers: The U.S. has more than 6.3 million confirmed cases and more than 189,600 deaths, according to Johns Hopkins University data. Globally, there are almost 27.6 million cases and more than 898,000 fatalities.
📰 What we're reading: A study by a California research group estimates that the Sturgis motorcycle rally in South Dakota led to more than 260,000 coronavirus cases in the month following the event. Gov. Kristi Noem called the study "fiction."
🗺️ Mapping coronavirus: Track the U.S. outbreak, state by state
This file will be updated throughout the day. For updates in your inbox, subscribe to The Daily Briefing newsletter.
Pope Francis: Health of all is a 'common good'
Pope Francis, in an appeal against the "partisan interests" emerging among some nations and groups during the COVID-19 pandemic, made a plea for all to look out for the health of others as well as themselves in a public address Wednesday.
"The coronavirus is showing us that each person’s true good is a common good and, vice versa, the common good is a true good for the person. Health, in addition to being an individual good, is also a public good. A healthy society is one that takes care of everyone’s health," Francis said.
Francis resumed his weekly public audiences last week after a six-month hiatus due to the pandemic. A limited crowd gathered to see Francis, with chairs were spaced out in the San Damaso courtyard inside the Apostolic Palace.
BioNTech CEO confident vaccine will be ready for approval by mid-October
BioNTech CEO and co-founder Ugur Sahin said in an interview with CNN that his company's vaccine being developed along with Pfizer could be ready for regulatory approval by mid-October or early November.
"It has an excellent profile and I consider this vaccine ... near perfect, and which has a near perfect profile," Sahin told CNN on Tuesday. Sahin's comments came the same day another candidate vaccine hit a snag as AstraZeneca hit pause on its trial after an unexplained illness.
The comments also come after BioNTech and Pfizer were among the nine biopharmaceutical companies that issued a letter Tuesday pledging to fully vet their COVID-19 candidate vaccines before asking for federal approval to market them.
President Donald Trump has repeatedly said a vaccine could be ready before the November election and that if it wasn't, it was because of a "deep state" conspiracy against him.
Majority of young adults live with their parents for first time since Great Depression
The number of 18- to 29-year-olds living with their parents reached record highs as more than half reported residing at home in July.
In February, 47% of young adults reported living at home. That number grew to 52% by July, or roughly an increase of 2.6 million people, according to data from the Pew Research Center.
The number is higher than any previous measurements, Pew says. At the end of the Great Depression, based on data from the 1940 census, 48% of young adults lived at home. The peak during the Great Depression may have been higher, but there is no available data, Pew says.
The economic impact of the coronavirus pandemic has been particularly hard for young Americans, and Pew's data show many moved home due to job loss or college campus closures.
Pennsylvania college football player dies of coronavirus complications
California University of Pennsylvania football player Jamain Stephens, 20, has died, the school announced Tuesday. Stephens, a senior defensive lineman, was the son of former Pittsburgh Steelers and Cincinnati Bengals offensive lineman Jamain Stephens.
Central Catholic High School in Pittsburgh, where Stephens played, said in a statement posted to Facebook on Tuesday his cause of death was related to complications involving COVID-19. It is unclear how he contracted the disease.
California University was not playing football this fall with COVID-19 health concerns forcing sports to be halted by the Pennsylvania State Athletic Conference. A cause of death was not given in the California University announcement.
– Erick Smith
Trump says North Carolina restrictions will hurt his reelection bid
President Donald Trump kicked off a campaign rally on Tuesday in Winston-Salem, North Carolina, by accusing the state's governor of using coronavirus restrictions to hurt his reelection chances.
"Your state should be open," Trump said to a crowd of hundreds that erupted in cheers at the Smith Reynolds Airport.
The president, still stung from the loss of the GOP convention that was due to take place in Charlotte last month but moved to a nearly all-virtual event over COVID-19, said North Carolina and other key battleground states such as Michigan were keeping their states shut for "political reasons."
"On Nov. 4, every one of those states will be open. They're doing it for political reasons," Trump said in remarks that lasted 76 minutes.
– John Fritze, Courtney Subramanian and David Jackson
Los Angeles sets COVID-19 guidelines ahead of Halloween celebrations
Los Angeles County health officials have set guidelines for Halloween celebrations amid the coronavirus pandemic. The city banned door-to-door trick-or-tricking, trunk-or-treating events where children receive treats from car-to-car, haunted houses, festivals and other related events.
"Door-to-door trick-or-treating is not allowed because it can be very difficult to maintain proper social distancing on porches and at front doors especially in neighborhoods that are popular with trick or treaters," the guidelines say.
Instead, officials are encouraging families to celebrate by attending virtual events, car parades, drive-in movie theaters and other activities that follow the city's public health guidelines.
TSA passenger screenings top 900,000 twice over Labor Day weekend
The Transportation Security Agency reported Tuesday that more people flew over the Labor Day weekend than at any other point in the COVID-19 pandemic. Some 935,308 passengers went through TSA checkpoints on Monday, setting a new record. That betters the previous high of 862,949 that was set on Aug. 16.
The number of passengers who went through TSA checkpoints went over 900,000 twice during the long holiday weekend – first on Friday with 968,673, then again on Monday. Thursday also saw higher-than-average traffic with 877,673 passengers being screened.
Though the TSA numbers approached 1 million for the first time since the country went on lockdown, they're still a far cry from Labor Day weekend in 2019, when more than 2 million passed through checkpoints all but one day.
– Jayme Deerwester
Honolulu extends stay-at-home order
Honolulu Mayor Kirk Caldwell announced Tuesday that he will extend an existing stay-at-home order for two weeks to control the coronavirus in Hawaii's largest city.
The stay-at-home order will be kept in place through Sept. 24. But Caldwell said he will modify the rules to allow solo activity at beaches, parks and trails. Individuals will be able to run, sit or eat by themselves in these public places beginning Thursday.
AstraZeneca halts COVID vaccine trials after 'unexplained illness' reported
AstraZeneca, one of the companies racing to make a vaccine against the coronavirus, put a hold on its COVID-19 clinical trials worldwide, while it investigated an adverse reaction in a trial participant in the United Kingdom.
The company, which is currently working with the University of Oxford on Phase 3 of testing its vaccine, said the pause was "a routine action which has to happen whenever there is a potentially unexplained illness in one of the trials."
The interruption represents the first major hiccup in what has been a remarkably smooth path in the historically rapid vaccine effort spanning the globe. That said, large scale, make-or-break Phase 3 clinical trials are where real issues are most likely to occur.
It remains unclear what the reaction is, or when it took place. Stat News reported that the individual is expected to recover.
– Elizabeth Weise and Karen Weintraub
COVID-19 resources from USA TODAY
- On Facebook: There's still a lot unknown about the coronavirus. But what we do know, we're sharing with you. Join our Facebook group, Coronavirus Watch, to receive daily updates in your feed and chat with others in the community about COVID-19.
- In your inbox: Stay up-to-date with the latest news on the coronavirus pandemic from the USA TODAY Network. Sign up for the daily Coronavirus Watch newsletter.
- Tips for coping: Every Saturday and Tuesday we'll be in your inbox, offering you a virtual hug and a little bit of solace in these difficult times. Sign up for Staying Apart, Together.
Contributing: The Associated Press
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